Complementarity-determining region 3 (CDR3) length distribution analysis explores the
diversity of the T cell receptor (TCR) and immunoglobulin (Ig) repertoire at the transcriptome …

In solid organ transplantation, the achievement of an immunosuppression (IS)-free state
[also referred to as clinical operational tolerance (COT)] represents the ultimate goal …

Establishing long-term allograft acceptance without the requirement for continuous
immunosuppression, a condition known as allograft tolerance, is a highly desirable …

Long-term allograft survival generally requires lifelong immunosuppression (IS). Rarely,
recipients display spontaneous “operational tolerance” with stable graft function in the …

Background. Although immunosuppression withdrawal in kidney recipients usually leads to
rejection, in some patients it does not, leading to a state of clinical operational tolerance …

Background We recently reported that durable chimerism can be safely established in
mismatched kidney recipients through nonmyeloablative conditioning followed by infusion of …

T-cell therapy after hematopoietic stem cell transplantation (HSCT) has been used alone or
in combination with immunosuppression to cure hematologic malignancies and to prevent …

MATERIALS AND METHODS All protocols are approved by the Northwestern University
(NWU) and University of Louisville Institutional Review Boards and the FDA (IDE 13947) …

Induction of allograft-specific tolerance and the detection of a “tolerance” state in recipients
under immunosuppression with long-term stable graft function are major challenges in …

A proportion of transplant recipients can spontaneously accept their grafts in the absence of
immunosuppression (operational tolerance). Previous studies identified blood …