Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …

Phototaxis behavior is commonly observed in animals with light-sensing organs. C. elegans,
however, is generally believed to lack phototaxis, as this animal lives in darkness (soil) and …

The oxidative damage theory of aging once seemed almost proven. Yet recently the
buzzards have been assembling in the blue skies above it. New challenges to the theory …

The free radical theory of aging proposes a causal relationship between reactive oxygen
species (ROS) and aging. While it is clear that oxidative damage increases with age, its role …

Background A powerful approach to understanding complex processes such as aging is to
use model organisms amenable to genetic manipulation, and to seek relevant phenotypes …

The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior
that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms …

Advances in the field of redox biology have contributed to the understanding of the
complexity of the thiol-based system in mediating signal transduction. The redox …

Many insights into the mechanisms and signaling pathways underlying aging have resulted
from research on the nematode Caenorhabditis elegans. In this paper, we discuss the recent …

The insulin/insulin-like peptides (ILPs) regulate key events in physiology, including neural
plasticity. However, the cellular and circuit mechanisms whereby ILPs regulate learning …