The tumor microenvironment is a dynamic landscape in which the physical and mechanical
properties evolve dramatically throughout cancer progression. These changes are driven by …

Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …

Current measurements of the biomechanical properties of cells require physical contact with
cells or lack subcellular resolution. Here we developed a label-free microscopy technique …

Dynamic biological measurements require low light levels to avoid damaging the specimen.
With this constraint on optical power, quantum noise fundamentally limits the measurement …

Mucus is a complex biological material that lubricates and protects the human lungs,
gastrointestinal (GI) tract, vagina, eyes, and other moist mucosal surfaces. Mucus serves as …

Cell differentiation in embryogenesis involves extensive changes in gene expression
structural reorganization within the nucleus, including chromatin condensation and …

A multitude of cellular and subcellular processes depend critically on the mechanical
deformability of the cytoplasm. We have recently introduced the method of particle-tracking …

We review pro and contra of the hypothesis that generic polymer properties of topological
constraints are behind many aspects of chromatin folding in eukaryotic cells. For that …

Cell migration controls developmental processes (gastrulation and tissue patterning), tissue
homeostasis (wound repair and inflammatory responses), and the pathobiology of diseases …