Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the
global population over 65 years of age. A hallmark feature of PD is the degeneration of the …

Aims: Protein aggregation and oxidative stress are both key pathogenic processes in
Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative …

Parkinson's disease (PD) is a chronic progressive neurodegenerative movement disorder
characterized by a profound and selective loss of nigrostriatal dopaminergic neurons …

Parkinson's disease (PD) is a complex disease, with genetics and environment contributing
to the disease onset. Recent studies of causative PD genes have confirmed the involvement …

Parkinson's disease is one of the most common neurodegenerative diseases. Animal
models have contributed a large part to our understanding and therapeutics developed for …

Background Mechanisms whereby gene–environment interactions mediate chronic,
progressive neurodegenerative processes in Parkinson's disease (PD)—the second most …