Recent insights into mechanisms of hypoxia‐induced vasodilatation in the human brain

JMJR Carr, RL Hoiland, IA Fernandes… - The Journal of …, 2024 - Wiley Online Library
The cerebral vasculature manages oxygen delivery by adjusting arterial blood in‐flow in the
face of reductions in oxygen availability. Hypoxic cerebral vasodilatation, and the associated …

Relationship between chronic hypoxia and seizure susceptibility

YH Xu, QL Fan - CNS Neuroscience & Therapeutics, 2022 - Wiley Online Library
Chronic hypobaric hypoxia in high‐altitude areas is closely related to the occurrence of
many neurological diseases. Among these diseases, epilepsy is a common disease of the …

Partial pressure of arterial oxygen in healthy adults at high altitudes: a systematic review and meta-analysis

A Forrer, T Gaisl, A Sevik, M Meyer, L Senteler… - JAMA network …, 2023 - jamanetwork.com
Importance With increasing altitude, the partial pressure of inspired oxygen decreases and,
consequently, the Pao 2 decreases. Even though this phenomenon is well known, the extent …

Lifelong exposure to high‐altitude hypoxia in humans is associated with improved redox homeostasis and structural–functional adaptations of the neurovascular unit

BS Stacey, RL Hoiland, HG Caldwell… - The Journal of …, 2023 - Wiley Online Library
High‐altitude (HA) hypoxia may alter the structural–functional integrity of the neurovascular
unit (NVU). Herein, we compared male lowlanders (n= 9) at sea level (SL) and after 14 days …

The 2018 global research expedition on altitude related chronic health (Global REACH) to Cerro de Pasco, Peru: an experimental overview

MM Tymko, RL Hoiland, JC Tremblay… - Experimental …, 2021 - Wiley Online Library
New Findings What is the central question of this study? Herein, a methodological overview
of our research team's (Global REACH) latest high altitude research expedition to Peru is …

To the extreme! How biological anthropology can inform exercise physiology in extreme environments

A Niclou, M Sarma, S Levy, C Ocobock - Comparative Biochemistry and …, 2023 - Elsevier
The fields of biological anthropology and exercise physiology are closely related and can
provide mutually beneficial insights into human performance. These fields often use similar …

[图书][B] Ward, milledge and west's high altitude medicine and physiology

AM Luks, PN Ainslie, JS Lawley, RC Roach… - 2021 - taylorfrancis.com
This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

Influence of iron manipulation on hypoxic pulmonary vasoconstriction and pulmonary reactivity during ascent and acclimatization to 5050 m

CK Willie, A Patrician, RL Hoiland… - The Journal of …, 2021 - Wiley Online Library
Key points Iron acts as a cofactor in the stabilization of the hypoxic‐inducible factor family,
and plays an influential role in the modulation of hypoxic pulmonary vasoconstriction. It is …

Cardiopulmonary and cerebrovascular acclimatization in children and adults at 3800 m

MG Rieger, CM Tallon, DR Perkins… - The Journal of …, 2022 - Wiley Online Library
Maturational differences exist in cardiopulmonary and cerebrovascular function at sea‐level,
but the impact of maturation on acclimatization responses to high altitude is unknown. Ten …

Research progress on the mechanism of cerebral blood flow regulation in hypoxia environment at plateau

GS Hao, QL Fan, QZ Hu, Q Hou - Bioengineered, 2022 - Taylor & Francis
The plateau is a special environment with low air pressure and low oxygen content. The
average altitude of Qinghai-Tibet is 3,500 m, and the atmospheric oxygen partial pressure in …