Cisplatin is one of the most widely used and most potent chemotherapy drugs. However,
side effects in normal tissues and organs, notably nephrotoxicity in the kidneys, limit the use …

Cisplatin (cis-diamminedichloroplatinum (II)) is an effective agent against various solid
tumours. Despite its effectiveness, the dose of cisplatin that can be administered is limited by …

The presence of renal dysfunction in a patient receiving chemotherapy can be devastating.
Although many patients with cancer have underlying compromised renal function, some …

Despite constant achievements in treatment, acute kidney injury (AKI) remains a significant
public health problem and a cause of mortality in the human population. In developed …

Hypoxia, which is commonly observed in many solid tumors, is a major impediment to
chemo-or radiation therapy. Hypoxia is also known to overexpress/activate signal transducer …

Cisplatin, an effective antineoplastic agent, frequently induces acute renal failure in animals
and humans. Hyperbaric oxygen (HBO) has been shown to prevent cisplatin-induced …

Although proteomics studies the global expression of proteins, metabolomics characterizes
and quantifies their end products: the metabolites, produced by an organism under a certain …

Aims Acute kidney injury (AKI) is a life-threatening condition marked by sudden kidney
function loss and azotemia. While its management is limited to supportive care, the effects of …

Tumor cells with different origins have different threshold to apoptosis. Hematopoietic
(Jurkat, NCI-H929) cells and non-hematopoietic (A549, MCF-7) cells were received …

Myoglobinuric acute renal failure (ARF) is a uremic syndrome caused by traumatic or non-
traumatic skeletal muscle breakdown and intracellular elements that are released into the …