Starting two decades ago with the discoveries of genetic links between alpha-synuclein and
Parkinson's disease risk and the identification of aggregated alpha-synuclein as the main …

Parkinson's disease (PD) is currently clinically defined by a set of cardinal motor features
centred on the presence of bradykinesia and at least one additional motor symptom out of …

Crohn's disease (CD), a form of inflammatory bowel disease, has a higher prevalence in
Ashkenazi Jewish than in non-Jewish European populations. To define the role of …

In the past two decades, mutations in multiple genes have been linked to autosomal
dominant or recessive forms of monogenic Parkinson's disease (PD). Collectively, these …

The kinase-activating mutation G2019S in leucine-rich repeat kinase 2 (LRRK2) is one of
the most common genetic causes of Parkinson's disease (PD) and has spurred development …

Synaptotagmin-11 (Syt11) is a vesicle-trafficking protein that is linked genetically to
Parkinson's disease (PD). Likewise, the protein α-synuclein regulates vesicle trafficking, and …

Human TMEM175, a noncanonical potassium (K+) channel in endolysosomes, contributes
to their pH stability and is implicated in the pathogenesis of Parkinson's disease (PD) …

Parkinson's disease (PD) is a neurodegenerative disorder whose pathogenesis depends on
a combination of genetic and environmental factors. The aim of the present review was to …

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant familial
Parkinson's disease (PD), with pathogenic mutations enhancing LRRK2 kinase activity …

Variants in the leucine-rich repeat kinase-2 (LRRK2) gene are associated with Parkinson's
disease, leprosy, and Crohn's disease, three disorders with inflammation as an important …