Itch is a common sensory experience that is prevalent in patients with inflammatory skin
diseases, as well as in those with systemic and neuropathic conditions. In patients with …

Itch pathogenesis is broadly characterized into histaminergic and nonhistaminergic
pathways and transmitted via 2 main receptor families: G protein–coupled receptors and …

Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the
skin, and the immune system. Histaminergic neurons in mammalian brain are located …

The neurobiology of itch, which is formally known as pruritus, and its interaction with pain
have been illustrated by the complexity of specific mediators, itch-related neuronal pathways …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

This review and meta-analysis aims at summarizing and integrating the human
neuroimaging studies that report periaqueductal gray (PAG) involvement; 250 original …

While considerable effort has been made to investigate the neural mechanisms of pain,
much less effort has been devoted to itch, at least until recently. However, itch is now gaining …

Itch, in particular chronic forms, has been widely recognized as an important clinical
problem, but much less is known about the mechanisms of itch in comparison with other …

Little is known about the neural correlates of tics and associated urges. In the present study,
we aimed to explore the neural basis of tics in patients with Tourette syndrome by using …

This Review highlights selected frontiers in pruritus research and focuses on recently
attained insights into the neurophysiological, neuroimmunological, and neuroendocrine …