Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms

U Nair, H Bartsch, J Nair - Mutagenesis, 2004 - academic.oup.com
Abstract In south‐east Asia, Taiwan and Papua New Guinea, smoking, alcohol consumption
and chewing of betel quid with or without tobacco or areca nut with or without tobacco are …

Genetic Polymorphism of CYP Genes, Alone or in Combination, as a Risk Modifier of Tobacco-related Cancers

H Bartsch, U Nair, A Risch, M Rojas, H Wikman… - … Biomarkers & Prevention, 2000 - AACR
Tobacco use is causally associated with cancers of the lung, larynx, mouth, esophagus,
kidneys, urinary tract, and possibly, breast. Major classes of carcinogens present in tobacco …

Clearing the smoke: assessing the science base for tobacco harm reduction

S Bondurant, R Wallace, P Shetty, K Stratton - 2001 - books.google.com
Despite overwhelming evidence of tobacco's harmful effects and pressure from anti-smoking
advocates, current surveys show that about one-quarter of all adults in the United States are …

Mammalian class theta GST and differential susceptibility to carcinogens: a review

S Landi - Mutation Research/Reviews in Mutation Research, 2000 - Elsevier
Glutathione S-transferases (GSTs) are an important part of the cellular detoxification system
and, perhaps, evolved to protect cells against reactive oxygen metabolites. Theta is …

Association of betel nut with carcinogenesis: revisit with a clinical perspective

RN Sharan, R Mehrotra, Y Choudhury, K Asotra - 2012 - journals.plos.org
Betel nut (BN), betel quid (BQ) and products derived from them are widely used as a socially
endorsed masticatory product. The addictive nature of BN/BQ has resulted in its widespread …

Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN): 1. Carcinogen metabolism, DNA repair and cell cycle control

C Scully, JK Field, H Tanzawa - Oral oncology, 2000 - Elsevier
The ability to metabolise carcinogens or pro-carcinogens, repair DNA damage, and control
cell signalling and the cell cycle are fundamental to homeostasis. Oral squamous cell …

The effects of tobacco use on oral health

ASK Sham, LK Cheung, LJ Jin, EF Corbet - Hong Kong Medical Journal, 2003 - hub.hku.hk
Objective. To review the effects of tobacco use on oral health, with particular emphasis on
the effects of periodontal diseases, dental implant failures, and risk of development of oral …

Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer

TT Sreelekha, K Ramadas, M Pandey, G Thomas… - Oral oncology, 2001 - Elsevier
Oral cancer ranks first among all cancers in males and is the third most common among
females in India. Tobacco-derived carcinogens are involved in the development of oral …

Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator

D Anantharaman, PM Chaubal, S Kannan… - …, 2007 - academic.oup.com
Oral cancer is the leading cancer type among Southeast Asian men and is causally
associated with the use of tobacco. Genetic polymorphisms in xenobiotic-metabolizing …

Tobacco-related diseases: is there a role for antioxidant micronutrient supplementation?

MG Traber, A van der Vliet, AZ Reznick… - Clinics in chest medicine, 2000 - Elsevier
Cigarette smoking is a major risk factor in a variety of human diseases, such as
cardiovascular diseases, oral and lung cancers, and chronic obstructive pulmonary …