Purpose Loneliness is increasingly recognised as the next critical public health issue. A
plausible reason for this concern may be related to emerging societal trends affecting the …

Loneliness is associated with increased morbidity and mortality. Deeper understanding of
neurobiological mechanisms underlying loneliness is needed to identify potential …

Humans survive and thrive through social exchange. Yet, social dependency also comes at
a cost. Perceived social isolation, or loneliness, affects physical and mental health, cognitive …

Increasing evidence suggests that perceived social isolation or loneliness is a major risk
factor for physical and mental illness in later life. This review assesses the status of research …

Social relationships promote health and wellbeing. Brain regions regulating social behavior
continue to develop throughout adolescence, as teens learn to navigate their social …

Social isolation has been recognized as a major risk factor for morbidity and mortality in
humans for more than a quarter century. The brain is the key organ of social connections …

When we clap our hands in synchrony, feel the sadness of a friend, or match our attitudes to
peer norms, we align our behavior with others. We propose here a model that views …

Loneliness is a distressing emotional state that motivates individuals to renew and maintain
social contact. It has been suggested that lonely individuals suffer from a cognitive bias …

Loneliness can be operationalized as the actual or perceived absence of those social
relationships that serve to meet basic emotional needs. In contrast to solitude, a chosen …

Importance Emotional and behavioral symptoms in cognitively normal older people may be
direct manifestations of Alzheimer disease (AD) pathophysiology at the preclinical stage …