Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

Many of melatonin's actions are mediated through interaction with the G-protein coupled
membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

An essential component of the human diet, L-tryptophan is critical in a number of metabolic
functions and has been widely used in numerous research and clinical trials. This review …

The kynurenine pathway is important in cellular energy generation and limiting cellular
ageing as it degrades about 90% of dietary tryptophan into the essential co-factor NAD+ …

Circadian and seasonal rhythms are a fundamental feature of all living organisms and their
organelles. Biological rhythms are responsible for daily food intake; the period of hunger …

Melatonin is a hormone with endocrine, paracrine and autocrine actions. It is involved in the
regulation of multiple functions, including the control of the gastrointestinal (GI) system under …

Jordan University of Science and Technology Page 1 Jordan University of Science and
Technology Faculty of Agriculture Nutrition & Food Technology Department NF382 Diet …

Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel
syndrome (IBS), and this role is likely to be multifactorial. The aim of this review was to …

Microbial dysbiosis has long been postulated to be associated with the pathogenesis of
inflammatory bowel disease (IBD). Although evidence supporting the anti-colitic effects of …