Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks
MD Wyatt, DL Pittman - Chemical research in toxicology, 2006 - ACS Publications
The chemical methylating agents methylmethane sulfonate (MMS) and N-methyl-N '-nitro-N-
nitrosoguanidine (MNNG) have been used for decades as classical DNA damaging agents …
nitrosoguanidine (MNNG) have been used for decades as classical DNA damaging agents …
Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER …
L Li, EE Connor, SH Berger, MD Wyatt - Biochemical pharmacology, 2005 - Elsevier
Thymidylate synthase (TS) is an important target of several chemotherapeutic agents.
During TS inhibition, dTTP levels decrease with a subsequent increase in dUTP. Uracil …
During TS inhibition, dTTP levels decrease with a subsequent increase in dUTP. Uracil …
Inhibition of poly (ADP-ribose) polymerization preserves the glutathione pool and reverses cytotoxicity in hydrogen peroxide-treated lymphocytes
M Marini, F Frabetti, MA Brunelli, MA Raggi - Biochemical pharmacology, 1993 - Elsevier
DNA damage caused by oxygen radicals activates poly (ADP-ribosyl) polymerase
(pADPRP), a nuclear enzyme that utilizes NAD+ as substrate. It has been demonstrated that …
(pADPRP), a nuclear enzyme that utilizes NAD+ as substrate. It has been demonstrated that …
Recovery of human lymphocytes damaged with γ-radiation or enzymatically produced oxygen radicals: different effects of poly (ADP-ribosyl) polymerase inhibitors
M Marini, G Zunica, M Tamba… - … journal of radiation …, 1990 - Taylor & Francis
Quiescent human lymphocytes were damaged in two different ways, both producing toxic
oxygen radicals: xanthine oxidase plus hypoxanthine (XOD/HYP), or γ-rays. Under …
oxygen radicals: xanthine oxidase plus hypoxanthine (XOD/HYP), or γ-rays. Under …
DNA REPAIR AND POLY (ADP-RIBOSE) SYNTHESIS IN HUMAN
JE Cleaver, WF Morgan - Transformation of Human Diploid …, 2024 - books.google.com
Poly (ADP-ribose) polymerase is a ubiquitous enzyme in eukaryotic nuclei. It responds
rapidly to DNA breakage, but the nature, purpose, and significance of this response is still a …
rapidly to DNA breakage, but the nature, purpose, and significance of this response is still a …
Multiple effects of 3-aminobenzamide on DNA damage induced by cisplatin (DDP) in DDP-sensitive and-resistant rat ovarian tumor cell lines
G Chen, WJ Zeller - Cancer letters, 1992 - Elsevier
To investigate the mechanisms by which 3-aminobenzamide (3AB) reverses cisplatin (DDP)
resistance in a rat ovarian tumor cell line, the effects of 3AB on DDP-induced DNA damage …
resistance in a rat ovarian tumor cell line, the effects of 3AB on DDP-induced DNA damage …
The sensitivities of SV40-transformed human fibroblasts to monofunctional and DNA-crosslinking alkylating agents
J Miyakoshi, DA Scudiero, J Allalunis-Turner… - Mutation Research/DNA …, 1991 - Elsevier
Abstract 4 repair-deficient (Mer−) and 2 repair-proficient (Mer+) lines of SV40-transformed
human fibroblasts were assayed for colony-forming ability after treatment with MNNG, methyl …
human fibroblasts were assayed for colony-forming ability after treatment with MNNG, methyl …
DNA repair and poly (ADP-ri-bose) synthesis in human fibroblasts and other cell types
JE Cleaver, WF Morgan - Transformation of Human Diploid …, 1990 - books.google.com
Poly (ADP-ribose) polymerase is a ubiquitous enzyme in eukaryotic nuclei. It responds
rapidly to DNA breakage, but the nature, purpose, and significance of this response is still a …
rapidly to DNA breakage, but the nature, purpose, and significance of this response is still a …
[图书][B] The influence of base excision repair and DNA polymerase β on therapy targeted at thymidylate synthase
L Li - 2005 - search.proquest.com
Thymidylate synthase (TS) is an important target for several chemotherapeutic agents.
Inhibition of TS results in a decreased TTP level and an increased dUTP level, and thus …
Inhibition of TS results in a decreased TTP level and an increased dUTP level, and thus …
[图书][B] Bioreductively targeted inhibitors of dna repair radiosensitisers and chemosensitisers
AE Shinkwin - 1997 - search.proquest.com
The resistance of hypoxic cells in poorly vascularised solid tumours to radiotherapy and
chemotherapy represents the major cause of the local failure of control of many cancers …
chemotherapy represents the major cause of the local failure of control of many cancers …