Research on psoriasis pathogenesis has largely increased knowledge on skin biology in
general. In the past 15 years, breakthroughs in the understanding of the pathogenesis of …

Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …

Psoriasis is a chronic, immune-mediated, inflammatory disease that is pathogenically driven
by proinflammatory cytokines. This article reviews the immunologic role of interleukin (IL)-17 …

Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of
intensive research because of its crucial role in the pathogenesis of different diseases …

Cytokines play a central role in the pathophysiology of autoimmune and inflammatory
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …

Objectives To assess long-term efficacy, safety and tolerability of secukinumab up to 104
weeks in patients with active PsA. Methods Patients with PsA (n= 397) were randomized to …

Objective To compare immune cell phenotype and function in psoriatic arthritis (PsA) versus
psoriasis in order to better understand the pathogenesis of PsA. Methods In‐depth …

Psoriasis, an inflammatory skin disease, and psoriatic arthritis (PsA), an inflammatory
arthritis, share clinical, genetic, and pathogenic factors and may be summed as one disease …

Patients with psoriasis are frequently obese and experience anxiety or suffer from
depressive disorders. The immunopathogenesis of psoriasis and indeed psoriatic arthritis is …

Coffee is one of the world's most consumed beverage. In the last decades, coffee
consumption has attracted a huge body of research due to its impact on health. Recent …