Obesity is a worldwide pandemic contributing to the hypertensive state and to the
cardiovascular morbidity leading to an increase in hospitalizations, events and cost to the …

Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2
diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be …

Rationale: Previous studies on the relationship between diabetes and arterial stiffness were
mostly cross-sectional. A few longitudinal studies focused on one single direction. Whether …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

The twin epidemic of obesity and diabetes is a major crisis globally. Several epidemiologic
studies reveal the parallel escalation of obesity and diabetes. The term 'diabesity'expresses …

Mechanotransduction plays a crucial role in vascular biology. One example of this is the
local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this …

Insulin is a major endocrine hormone also involved in the regulation of energy and lipid
metabolism via the activation of an intracellular signaling cascade involving the insulin …

Hypertensive eye disease includes a spectrum of pathological changes, the most well
known being hypertensive retinopathy. Other commonly involved parts of the eye in …

Purpose: To analyze the foveal microvasculature in eyes with diabetic retinopathy (DR)
using optical coherence tomography angiography (OCTA) and fluorescein angiography …

The development of novel, non-invasive techniques and standardization of protocols to
assess microvascular dysfunction have elucidated the key role of microvascular changes in …