As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

The prevalence of osteoarthritis (OA) is rising for reasons that are not fully understood. In this
Opinion article, we review the possibility that OA is an evolutionary mismatch disease, which …

Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …

Background Osteoarthritis is generally a slowly progressive disorder. However, at least 1 in
7 people with incident knee osteoarthritis develop an abrupt progression to advanced-stage …

Objective Obesity was once considered a risk factor for knee osteoarthritis (OA) primarily for
biomechanical reasons. Here we provide an additional perspective by discussing how …

Objective MicroRNA‐34a‐5p (miR‐34a‐5p) expression is elevated in the synovial fluid of
patients with late‐stage knee osteoarthritis (OA); however, its exact role and therapeutic …

Osteoarthritis (OA) affects 240 million people globally. Few studies have examined the links
between osteoarthritis and the Mediterranean diet (MD). The aim of this paper was to …

Osteoarthritis (OA) is a painful and disabling disease that affects millions of people
worldwide. Symptom-alleviating treatments exist, although none with long-term efficacy …

To avoid autoimmunity, it is essential to keep the balance between the defence against
pathogens and the maintenance of tolerance to self‐antigens. Mucosal inflammation may …

Purpose Osteoarthritis (OA) is a joint disease that is clinically diagnosed using components
of history, physical exam, and characteristic radiographic findings, such as joint space …