Research on the Gram-positive human-restricted pathogen Streptococcus pyogenes (Group
A Streptococcus, GAS) has long focused on invasive illness, the most severe manifestations …

Background Group A Streptococcus (GAS) causes multiple clinical manifestations, including
invasive (iGAS) or even life-threatening (severe-iGAS) infections. After the drop in cases …

Streptococcus pyogenes is a species of Gram-positive bacteria. It is also known as Group A
Streptococcus (GAS) that causes pathogenesis to humans only. The GAS infection has …

Background The genomic features and transmission link of circulating Group A
Streptococcus (GAS) strains causing different disease types, such as pharyngitis and …

To evaluate the importance of covRS and ropB mutations in invasive disease caused by
Group A Streptococci (GAS), we determined the sequence of the covRS and ropB genes of …

The frequent occurrence of disease outbreaks in humans caused by group A Streptococcus
(GAS) is an on-going public health threat. Conventional bacterial typing methods lack the …

Streptococcus pyogenes, also known as group A Streptococcus, causes a wide variety of
diseases ranging from mild noninvasive to severe invasive infections. To identify possible …

Streptococcus pyogenes serotype M1 is a frequent cause of severe infections in humans.
Some M1 isolates are pathogenic in mice and used in studies on infection pathogenesis. We …

CovR/CovS is a two-component regulatory system in group A Streptococcus and primarily
acts as a transcriptional repressor. The D53 residue of CovR (CovRD53) is phosphorylated …

Although skin and soft tissue infections (SSTI) are the most common focal infections
associated with invasive disease caused by Streptococcus pyogenes (Lancefield Group A …