The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

BACKGROUND: Exosome therapy shows potential for cardiac repair after injury. However,
intrinsic challenges such as short half-life and lack of clear targets hinder the clinical …

The epicardium, previously viewed as a passive outer layer around the heart, is now
recognized as an essential component in development, regeneration, and repair. In this …

Abnormal cardiac development has been observed in individuals with Cornelia de Lange
syndrome (CdLS) due to mutations in genes encoding members of the cohesin complex …

Heart development relies on a topologically defined interplay between a diverse array of
cardiac cells. We finely curated spatial and single-cell measurements with subcellular …

Illuminating the precise stepwise genetic programs directing cardiac development provides
insights into the mechanisms of congenital heart disease and strategies for cardiac …

Abstract Tbx18, Wt1, and Tcf21 have been identified as epicardial markers during the early
embryonic stage. However, the gene markers of mature epicardial cells remain unclear …

Pericytes are essential for capillary stability and homeostasis, with impaired pericyte function
linked to diseases like pulmonary arterial hypertension. Investigating pericyte biology has …

Extensive genetic studies have elucidated cardiomyocyte differentiation and associated
gene networks using single-cell RNA-seq, yet the intricate transcriptional mechanisms …

Recent advancements in single‐cell technologies have led to rapid developments in the
construction of cell atlases. These atlases have the potential to provide detailed information …