[PDF][PDF] ISPAD Clinical Practice Consensus Guidelines 2022: Stages of type 1 diabetes in children and adolescents.
ISPAD clinical practice consensus guidelines 2022: Stages of type 1 diabetes in children and
adolescents Page 1 ISPAD GUIDELINES ISPAD clinical practice consensus guidelines 2022 …
adolescents Page 1 ISPAD GUIDELINES ISPAD clinical practice consensus guidelines 2022 …
Type 1 diabetes mellitus
A Katsarou, S Gudbjörnsdottir, A Rawshani… - Nature reviews Disease …, 2017 - nature.com
Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease
characterized by insulin deficiency due to pancreatic β-cell loss and leads to …
characterized by insulin deficiency due to pancreatic β-cell loss and leads to …
[HTML][HTML] Modulation of myelopoiesis progenitors is an integral component of trained immunity
I Mitroulis, K Ruppova, B Wang, LS Chen, M Grzybek… - Cell, 2018 - cell.com
Trained innate immunity fosters a sustained favorable response of myeloid cells to a
secondary challenge, despite their short lifespan in circulation. We thus hypothesized that …
secondary challenge, despite their short lifespan in circulation. We thus hypothesized that …
Genetic risk factors for type 1 diabetes
F Pociot, Å Lernmark - The Lancet, 2016 - thelancet.com
Type 1 diabetes is diagnosed at the end of a prodrome of β-cell autoimmunity. The disease
is most likely triggered at an early age by autoantibodies primarily directed against insulin or …
is most likely triggered at an early age by autoantibodies primarily directed against insulin or …
Timing of allergenic food introduction to the infant diet and risk of allergic or autoimmune disease: a systematic review and meta-analysis
Importance Timing of introduction of allergenic foods to the infant diet may influence the risk
of allergic or autoimmune disease, but the evidence for this has not been comprehensively …
of allergic or autoimmune disease, but the evidence for this has not been comprehensively …
Current and future therapies for type 1 diabetes
BJ von Scholten, FF Kreiner, SCL Gough… - Diabetologia, 2021 - Springer
In type 1 diabetes, insulin remains the mature therapeutic cornerstone; yet, the increasing
number of individuals developing type 1 diabetes (predominantly children and adolescents) …
number of individuals developing type 1 diabetes (predominantly children and adolescents) …
Antigen-specific therapeutic approaches for autoimmunity
P Serra, P Santamaria - Nature biotechnology, 2019 - nature.com
The main function of the immune system in health is to protect the host from infection by
microbes and parasites. Because immune responses to nonself bear the risk of unleashing …
microbes and parasites. Because immune responses to nonself bear the risk of unleashing …
A combined risk score enhances prediction of type 1 diabetes among susceptible children
Abstract Type 1 diabetes (T1D)—an autoimmune disease that destroys the pancreatic islets,
resulting in insulin deficiency—often begins early in life when islet autoantibody appearance …
resulting in insulin deficiency—often begins early in life when islet autoantibody appearance …
Early prediction of autoimmune (type 1) diabetes
SE Regnell, Å Lernmark - Diabetologia, 2017 - Springer
Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA
haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children …
haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children …
Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
S Culina, AI Lalanne, G Afonso, K Cerosaletti… - Science …, 2018 - science.org
The human leukocyte antigen–A2 (HLA-A2)–restricted zinc transporter 8186–194 (ZnT8186–
194) and other islet epitopes elicit interferon-γ secretion by CD8+ T cells preferentially in …
194) and other islet epitopes elicit interferon-γ secretion by CD8+ T cells preferentially in …