Connecting the molecular world to biology requires understanding how molecular-scale
dynamics propagate upward in scale to define the function of biological structures. To …

With the rapid development of computer power and wide availability of modelling software
computer simulations of realistic models of lipid membranes, including their interactions with …

Functioning as key players in cellular regulation of membrane curvature, BAR domain
proteins bend bilayers and recruit interaction partners through poorly understood …

Interdependence across time and length scales is common in biology, where atomic
interactions can impact larger-scale phenomenon. Such dependence is especially true for a …

There are several examples of membrane-associated protein domains that target curved
membranes. This behavior is believed to have functional significance in a number of …

Abstract Proteins containing a Bin/Amphiphysin/Rvs (BAR) domain regulate membrane
curvature in the cell. Recent simulations have revealed that BAR proteins assemble into …

Adhesion and insertion of curvature-mediating proteins can induce dramatic structural
changes in cell membranes, allowing them to participate in several key cellular tasks. The …

Rapid development of computer power during the last decade has made molecular
simulations of lipid bilayers feasible for many research groups, which, together with the …

Characterizing atomic details of membrane binding of peripheral membrane proteins by
molecular dynamics (MD) has been significantly hindered by the slow dynamics of …

Using a combination of X-ray scattering, fluorescence correlation spectroscopy, coarse-
grained molecular dynamics (MD) simulations and potential of mean force calculations, we …