Wound healing is one of the most complex biological processes to occur in life. Repair of
tissue following injury involves dynamic interactions between multiple cell types, growth …

Primary open angle glaucoma is a common eye disease characterized by loss of the axons
of the retinal ganglion cells leading to progressive loss of vision. The site of damage to the …

Due to their permanent and close proximity to neurons, glial cells perform essential tasks for
the normal physiology of the retina. Astrocytes and Müller cells (retinal macroglia) provide …

Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide.
We performed a genome-wide association study in an Australian discovery cohort …

Transforming growth factor-β2 (TGF-β2) is found in increasing amounts in aqueous humor
and reactive optic nerve astrocytes of patients with primary open-angle glaucoma (POAG), a …

purpose. To investigate the effect of IOP on retinal ganglion cell (RGC) apoptosis and
correlate the effects with IOP-induced changes in extracellular matrix (ECM) in the retina and …

Genome-editing technologies have ushered in a new era in gene therapy, providing novel
therapeutic strategies for a wide range of diseases, including both genetic and nongenetic …

To investigate the distribution and potential participation of microglia, the resident defense
cells of the central nervous system, in the optic nerve head (ONH) in glaucoma, histological …

Glaucoma, the second leading cause of blindness, is characterized by changes in the optic
disc and visual field defects. The elevated intraocular pressure was considered the prime …

purpose. In glaucoma, the optic nerve head (ONH) is the likely site of initial injury and
elevated intraocular pressure (IOP) is the best-known risk factor. This study determines …