Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with
age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal …

The family of fibroblast growth factors (FGFs) regulates a plethora of developmental
processes, including brain patterning, branching morphogenesis and limb development …

Osteoarthritis is a common joint disease for which there are currently no disease-modifying
drugs available. Degradation of the cartilage extracellular matrix is a central feature of the …

Background Full-thickness chondral defects and early osteoarthritis continue to present
major challenges for the patient and the orthopaedic surgeon as a result of the limited …

Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of
life and increased health costs. To understand this disease, physicians have been studying …

Osteochondral defect management and repair remain a significant challenge in orthopedic
surgery. Osteochondral defects contain damage to both the articular cartilage as well as the …

Abstract Runt-related transcription factor-1 (Runx1) is required for chondrocyte-to-osteoblast
lineage commitment by enhancing both chondrogenesis and osteogenesis during …

Joint trauma can lead to a spectrum of acute lesions, including osteochondral fractures,
ligament or meniscus tears and damage to the articular cartilage. This is often associated …

Osteoarthritis (OA) is a prevalent and disabling condition for which few safe and effective
therapeutic options are available. Current approaches are largely palliative and in an effort …

In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine
balance between anabolic and catabolic activities. In ageing, degenerative joint diseases …