Navigating Available Treatment Options for Carbapenem-Resistant Acinetobacter baumannii-calcoaceticus Complex Infections

RK Shields, DL Paterson… - Clinical Infectious …, 2023 - academic.oup.com
Carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRAB) is one of
the top-priority pathogens for new antibiotic development. Unlike other antibiotic-resistant …

Clinical challenges treating Stenotrophomonas maltophilia infections: an update

MF Mojica, R Humphries, JJ Lipuma… - JAC-antimicrobial …, 2022 - academic.oup.com
Stenotrophomonas maltophilia is a non-fermenting, Gram-negative bacillus that has
emerged as an opportunistic nosocomial pathogen. Its intrinsic multidrug resistance makes …

A novel antibiotic class targeting the lipopolysaccharide transporter

C Zampaloni, P Mattei, K Bleicher, L Winther, C Thäte… - Nature, 2024 - nature.com
Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global
pathogen with limited treatment options. No new antibiotic chemical class with activity …

Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery

Y Yang, YH Yan, CJ Schofield, A McNally, Z Zong… - Trends in …, 2023 - cell.com
Resistance to β-lactam antibiotics is rapidly growing, substantially due to the spread of
serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs), which efficiently catalyse β …

[PDF][PDF] Renal and hepatic dosing adjustments for cephalosporins

I Karunarathna, P Gunasena, T Hapuarachchi… - 2024 - researchgate.net
Cephalosporins are a class of β-lactam antimicrobials employed in treating a wide array of
infections caused by both gram-positive and gram-negative bacteria. The five generations of …

Carbapenem-resistant Acinetobacter baumannii: Colonization, Infection and Current Treatment Options

C Bartal, KVI Rolston, L Nesher - Infectious diseases and therapy, 2022 - Springer
Carbapenem-resistant Acinetobacter baumannii (CRAB) causes colonization and infection
predominantly in hospitalized patients. Distinction between the two is a challenge. When …

[HTML][HTML] European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram …

M Paul, E Carrara, P Retamar, T Tängdén… - Clinical Microbiology …, 2022 - Elsevier
Scope These ESCMID guidelines address the targeted antibiotic treatment of third-
generation cephalosporin-resistant Enterobacterales (3GCephRE) and carbapenem …

Serratia marcescens antibiotic resistance mechanisms of an opportunistic pathogen: a literature review

F Tavares-Carreon, K De Anda-Mora, IC Rojas-Barrera… - PeerJ, 2023 - peerj.com
Serratia marcescens is a ubiquitous bacterium from order Enterobacterales displaying a
high genetic plasticity that allows it to adapt and persist in multiple niches including soil …

Acinetobacter baumannii in the critically ill: complex infections get complicated

I Cavallo, A Oliva, R Pages, F Sivori, M Truglio… - Frontiers in …, 2023 - frontiersin.org
Acinetobacter baumannii is increasingly associated with various epidemics, representing a
serious concern due to the broad level of antimicrobial resistance and clinical …

[PDF][PDF] Cefiderocol and cephalosporins: A novel approach to managing resistant Gram-negative bacterial infections

I Karunarathna, P Gunasena, T Hapuarachchi… - 2024 - researchgate.net
Cephalosporins are a class of β-lactam antimicrobials employed in treating a wide array of
infections caused by both gram-positive and gram-negative bacteria. The five generations of …