Pulmonary arterial hypertension: a current perspective on established and emerging molecular genetic defects
Pulmonary arterial hypertension (PAH) is an often fatal disorder resulting from several
causes including heterogeneous genetic defects. While mutations in the bone …
causes including heterogeneous genetic defects. While mutations in the bone …
Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms
F Sotgia, UE Martinez-Outschoorn… - Annual Review of …, 2012 - annualreviews.org
Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …
Molecular architecture of the human caveolin-1 complex
Membrane-sculpting proteins shape the morphology of cell membranes and facilitate
remodeling in response to physiological and environmental cues. Complexes of the …
remodeling in response to physiological and environmental cues. Complexes of the …
Lipodystrophy: pathophysiology and advances in treatment
CG Fiorenza, SH Chou, CS Mantzoros - Nature Reviews Endocrinology, 2011 - nature.com
Lipodystrophy is a medical condition characterized by complete or partial loss of adipose
tissue. Not infrequently, lipodystrophy occurs in combination with pathological accumulation …
tissue. Not infrequently, lipodystrophy occurs in combination with pathological accumulation …
Stromal–epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment
UE Martinez-Outschoorn, S Pavlides, A Howell… - The international journal …, 2011 - Elsevier
Cancer cells do not exist as pure homogeneous populations in vivo. Instead they are
embedded in “cancer cell nests” that are surrounded by stromal cells, especially cancer …
embedded in “cancer cell nests” that are surrounded by stromal cells, especially cancer …
Caveolae at a glance
M Bastiani, RG Parton - Journal of cell science, 2010 - journals.biologists.com
3832 et al., 2009; Hill et al., 2008; McMahon et al., 2009) have revealed additional levels of
complexity in the regulation of caveola formation and function. In this review, we summarize …
complexity in the regulation of caveola formation and function. In this review, we summarize …
Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility
Caveolins (CAVs) are essential components of caveolae, plasma membrane invaginations
with reduced fluidity, reflecting cholesterol accumulation [1]. CAV proteins bind cholesterol …
with reduced fluidity, reflecting cholesterol accumulation [1]. CAV proteins bind cholesterol …
The genetics of pulmonary arterial hypertension
ED Austin, JE Loyd - Circulation research, 2014 - Am Heart Assoc
Pulmonary arterial hypertension (PAH) is a progressive and fatal disease for which there is
an ever-expanding body of genetic and related pathophysiological information on disease …
an ever-expanding body of genetic and related pathophysiological information on disease …
Caveolinopathies: from the biology of caveolin-3 to human diseases
In muscle tissue the protein caveolin-3 forms caveolae–flask-shaped invaginations localized
on the cytoplasmic surface of the sarcolemmal membrane. Caveolae have a key role in the …
on the cytoplasmic surface of the sarcolemmal membrane. Caveolae have a key role in the …
Caveolae: the faqs
Caveolae are an abundant, but enigmatic, plasma membrane feature of vertebrate cells. In
this brief commentary, the authors attempt to answer some key questions related to the …
this brief commentary, the authors attempt to answer some key questions related to the …