In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Acid-sensing ion channels (ASICs) are Na+-permeable ion channels activated by protons
and predominantly expressed in the nervous system. ASICs act as pH sensors leading to …

Acetazolamide is an old drug used as an antiepileptic agent, amongst other indications. The
drug is seldom used, primarily due to perceived poor efficacy and adverse events …

Life on Planet Earth, as we know it, revolves around adenosine triphosphate (ATP) as a
universal energy storing molecule. The metabolism of ATP requires a low cytosolic Ca2+ …

Extracellular pH changes may constitute significant signals for neuronal communication.
During synaptic transmission, changes in pH in the synaptic cleft take place. Its role in the …

Background The ketogenic diet (KD) is a proven therapy for refractory epilepsy. Although the
anti-seizure properties of this diet are understood to a certain extent, the exploration of its …

Acid-sensitive ion channels (ASICs) are cationic channels activated by extracellular protons
and widely distributed in the nervous system of mammals. It belongs to the ENaC/DEG …

Background Anterior cruciate ligament injury arises when the knee anterior ligament fibers
are stretched, partially torn, or completely torn. Operated patients either end up re-injuring …

Epilepsy, a prevalent neurological disorder characterized by spontaneous recurrent
seizures, significantly impacts physiological and cognitive functions. Emerging evidence …

Adenosine triphosphate (ATP) is well-known as a universal source of energy in living cells.
Less known is that this molecule has a variety of important signaling functions: it activates a …