Senescence is a cellular state characterized by its near-permanent halted cell cycle and
distinct secretory phenotype. Although senescent cells have a variety of beneficial …

Cells can communicate in a variety of ways, such as by contacting each other or by secreting
certain factors. Recently, extracellular vesicles (EVs) have been proposed to be mediators of …

Population-level variation and mechanisms behind insulin secretion in response to
carbohydrate, protein, and fat remain uncharacterized. We defined prototypical insulin …

Pharmacologically active compounds that manipulate cellular senescence (senotherapies)
have recently shown great promise in multiple pre-clinical disease models, and some of …

Cellular senescence is a kind of cellular state triggered by endogenous or exogenous
stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence …

Sublethal cell damage can trigger senescence, a complex adaptive program characterized
by growth arrest, resistance to apoptosis and a senescence-associated secretory phenotype …

Background Alzheimer's disease (AD) is a leading cause of dementia. The aging brain is
particularly vulnerable to various stressors, including increased levels of ceramide …

Cellular senescence is characterized by cell cycle arrest, resistance to apoptosis, and a
senescence-associated secretory phenotype (SASP) whereby cells secrete pro …

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is prone to
metastasis and therapy resistance. Owing to its aggressive nature and limited availability of …

Cell senescence is the growth arrest caused by the accumulation of irreparable cell
damage, which is involved in physiological and pathological processes and regulated by the …