There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

Acute kidney injury (AKI) is a common and morbid complication after severe burn, with an
incidence and mortality as high as 30% and 80%, respectively. AKI is a broad clinical …

Background After a single-center trial and observational studies suggesting that early, goal-
directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials …

Importance The effect of an early resuscitation protocol on sepsis outcomes in developing
countries remains unknown. Objective To determine whether an early resuscitation protocol …

Prompt intravenous fluid therapy is a fundamental treatment for patients with septic shock.
However, the optimal approach for administering intravenous fluid in septic shock …

Sepsis and septic shock are syndromes of immense clinical importance. Suspected sepsis
accounts for more than half a million emergency department visits annually in the United …

Between 2014 and 2015, 3 independent, multicenter, government-funded, randomized
controlled trials (RCTs) evaluating early goal-directed therapy (EGDT) were published …

The 28th edition of Bailey & Love's Short Practice of Surgery is the leading surgical resource
for medical students and surgeons in training. It encompasses the basic principles of careful …

Patients undergoing complex gastrointestinal surgery are at high risk of major postoperative
complications (eg, anastomotic leakage, sepsis), classified as Clavien-Dindo (CD)≥ IIIa …

The most recent definition of sepsis in human medicine can be summarized as organ
dysfunction caused by a dysregulated host response to infection. In equine medicine …