Selenium and selenoproteins in health

F Zhang, X Li, Y Wei - Biomolecules, 2023 - mdpi.com
Selenium is a trace mineral that is essential for health. After being obtained from food and
taken up by the liver, selenium performs various physiological functions in the body in the …

Distinct roles of SELENOF in different human cancers

B Flowers, O Bochnacka, A Poles, AM Diamond… - Biomolecules, 2023 - mdpi.com
SELENOF, previously known as SEP15, is a selenoprotein that contains selenium in the
form of the amino acid selenocysteine. Like other selenoproteins, the role for SELENOF in …

Association of Dietary Intake of Zinc and Selenium with Breast Cancer Risk: A Case-Control Study in Chinese Women

K Tu, K Liu, Y Wang, Y Jiang, C Zhang - Nutrients, 2023 - mdpi.com
As major nonenzymatic antioxidant components in the body, dietary Zinc (Zn) and Selenium
(Se) may have an impact on breast cancer development. This study aimed to investigate the …

[HTML][HTML] High throughput drug screening identifies resveratrol as suppressor of hepatic SELENOP expression

J Hackler, K Demircan, TS Chillon, Q Sun, N Geisler… - Redox Biology, 2023 - Elsevier
Abstract Introduction Selenium (Se) is an essential trace element that exerts its effects
mainly as the proteinogenic amino acid selenocysteine within a small set of selenoproteins …

Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study

K Demircan, Y Bengtsson, TS Chillon… - Journal of Translational …, 2023 - Springer
Introduction Low serum selenium and altered tumour RNA expression of certain
selenoproteins are associated with a poor breast cancer prognosis. Selenoprotein …

[HTML][HTML] Beneficial Effects of Selenium and Its Supplementation on Carcinogenesis and the Use of Nanoselenium in the Treatment of Malignant Tumors

M Maleczek, J Reszeć-Giełażyn… - International Journal of …, 2024 - mdpi.com
Selenium was recognized as a non-toxic element in the second half of the 20th century.
Since then, the positive impact of selenium on the functioning of the human body has been …

[HTML][HTML] Biosynthesis of selenium nanoparticles as a potential therapeutic agent in breast cancer: G2/M arrest and apoptosis induction

BA Ali, RM Allam, MS Hasanin, AA Hassabo - Toxicology Reports, 2024 - Elsevier
The drawbacks and adverse reactions of conventional breast cancer (BC) medications have
prompted researchers to seek novel therapeutic approaches. This study aimed to study the …

Diphenyl Diselenide Through Reduction of Inflammation, Oxidative Injury and Caspase-3 Activation Abates Doxorubicin-Induced Neurotoxicity in Rats

OF Da-Silva, AR Adelowo, AA Babalola, CN Ikeji… - Neurochemical …, 2024 - Springer
Neurotoxicity associated with chemotherapy is a debilitating side effect of cancer
management in humans which reportedly involves inflammatory and oxidative stress …

Modification Effects of Homologous Recombination Repair Gene Polymorphisms on the Associations Between Urinary Metals and Breast Cancer Risk

S Han, M Lu, Y Zhang, Y Lin, Q Liu, L Xu… - Biological Trace Element …, 2024 - Springer
Metals are recognized as important factors related to breast cancer (BC) risk. Homologous
recombination repair (HRR) genes might modify the toxicity of metals by influencing the …

Inhibition of Selenoprotein I promotes ferroptosis and reverses resistance to platinum chemotherapy by impairing Akt phosphorylation in ovarian cancer

J Li, M Chen, D Huang, Z Li, Y Chen, J Huang… - MedComm, 2024 - Wiley Online Library
Ovarian cancer (OV) ranks among the deadliest gynecological cancer, known for its high risk
of relapse and metastasis, and a general resistance to conventional platinum‐based …