Trace amines and their receptors

RR Gainetdinov, MC Hoener, MD Berry… - Pharmacological …, 2018 - Elsevier
Trace amines are endogenous compounds classically regarded as comprising β-
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …

[HTML][HTML] Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges

MD Berry, RR Gainetdinov, MC Hoener… - Pharmacology & …, 2017 - Elsevier
The discovery in 2001 of a G protein-coupled receptor family, subsequently termed trace
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …

The case for TAAR1 as a modulator of central nervous system function

G Rutigliano, A Accorroni, R Zucchi - Frontiers in pharmacology, 2018 - frontiersin.org
TAAR1 is widely expressed across the mammalian brain, particularly in limbic and
monoaminergic areas, allegedly involved in mood, attention, memory, fear, and addiction …

Trace amines and the trace amine-associated receptor 1: pharmacology, neurochemistry, and clinical implications

Y Pei, A Asif-Malik, JJ Canales - Frontiers in neuroscience, 2016 - frontiersin.org
Biogenic amines are a collection of endogenous molecules that play pivotal roles as
neurotransmitters and hormones. In addition to the “classical” biogenic amines resulting …

Pronounced hyperactivity, cognitive dysfunctions, and BDNF dysregulation in dopamine transporter knock-out rats

D Leo, I Sukhanov, F Zoratto, P Illiano… - Journal of …, 2018 - Soc Neuroscience
Dopamine (DA) controls many vital physiological functions and is critically involved in
several neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity …

TAAR1 modulates cortical glutamate NMDA receptor function

S Espinoza, G Lignani, L Caffino, S Maggi… - …, 2015 - nature.com
Abstract Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor
expressed in the mammalian brain and known to influence subcortical monoaminergic …

The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors

D De Gregorio, L Posa, R Ochoa-Sanchez… - Pharmacological …, 2016 - Elsevier
Abstract d-lysergic diethylamide (LSD) is a hallucinogenic drug that interacts with the
serotonin (5-HT) system binding to 5-HT 1 and 5-HT 2 receptors. Little is known about its …

Postsynaptic D2 dopamine receptor supersensitivity in the striatum of mice lacking TAAR1

S Espinoza, V Ghisi, M Emanuele, D Leo, I Sukhanov… - …, 2015 - Elsevier
Abstract Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor
(GPCR) known to modulate dopaminergic system through several mechanisms. Mice …

Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases

MD Schwartz, JJ Canales, R Zucchi… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: The trace amines, endogenous amines closely related to the biogenic amine
neurotransmitters, have been known to exert physiological and neurological effects for …

Molecular variants in human trace amine-associated receptors and their implications in mental and metabolic disorders

G Rutigliano, R Zucchi - Cellular and Molecular Neurobiology, 2020 - Springer
We provide a comprehensive review of the available evidence on the pathophysiological
implications of genetic variants in the human trace amine-associated receptor (TAAR) …