From donor to the lab: a fascinating journey of primary cell lines

M Richter, O Piwocka, M Musielak… - Frontiers in Cell and …, 2021 - frontiersin.org
Primary cancer cell lines are ex vivo cell cultures originating from resected tissues during
biopsies and surgeries. Primary cell cultures are objects of intense research due to their …

Role of intracellular iron in switching apoptosis to ferroptosis to target therapy-resistant cancer stem cells

SL Pandrangi, P Chittineedi, SS Chalumuri, AS Meena… - Molecules, 2022 - mdpi.com
Iron is a crucial element required for the proper functioning of the body. For instance,
hemoglobin is the vital component in the blood that delivers oxygen to various parts of the …

Establishment and characterization of a receptor-negative, hormone-nonresponsive breast cancer cell line from an Iraqi patient

AM Al-Shammari, MA Alshami, MA Umran… - … Cancer: Targets and …, 2015 - Taylor & Francis
A new breast cancer cell line (AMJ13) has been established from an Iraqi breast cancer
patient. It is considered unique because it is the first for an Iraqi population, and is expected …

Role of lipoproteins in the pathophysiology of breast cancer

SL Pandrangi, P Chittineedi, R Chikati, JAN Mosquera… - Membranes, 2022 - mdpi.com
Breast cancer is one of the most common malignancies in women and the leading cause of
cancer mortality. Hypercholesterolemia and obesity are potential risk factors for the …

The role of obesity in breast cancer pathogenesis

I Glassman, N Le, A Asif, A Goulding, CA Alcantara… - Cells, 2023 - mdpi.com
Research has shown that obesity increases the risk for type 2 diabetes mellitus (Type 2 DM)
by promoting insulin resistance, increases serum estrogen levels by the upregulation of …

Navigating challenges: optimising methods for primary cell culture isolation

O Piwocka, M Musielak, K Ampuła, I Piotrowski… - Cancer Cell …, 2024 - Springer
Primary cell lines are invaluable for exploring cancer biology and investigating novel
treatments. Despite their numerous advantages, primary cultures are laborious to obtain and …

Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma

D Su, D Zhang, J Jin, L Ying, M Han, K Chen… - Nature …, 2019 - nature.com
Previous studies from the Cancer Cell Line Encyclopedia (CCLE) project have adopted
commercial pan-cancer cell line models to identify drug sensitivity biomarkers. However …

Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1

R Ali, N Samman, H Al Zahrani, A Nehdi, S Rahman… - BMC cancer, 2017 - Springer
Background Breast cancer is one of the most common cancer and a leading cause of death
in women. Up to date the most commonly used breast cancer cell lines are originating from …

Polyherbal formulation conjugated to gold nanoparticles induced ferroptosis in drug-resistant breast cancer stem cells through ferritin degradation

P Chittineedi, A Mohammed… - Frontiers in …, 2023 - frontiersin.org
Aim: Due to their minimal side effects, the anti-cancer properties of the polyherbal
formulation are being investigated. However, due to their low absorption potential, the …

Cell–cell communications: new insights into targeting efficacy of phytochemical adjuvants on tight junctions and pathophysiology of various malignancies

SL Pandrangi, P Chittineedi, GJ Mohiddin… - Journal of Cell …, 2023 - Springer
Cancer is a cellular impairment disorder characterized by the loss of cell cycle regulation
leading to aberrant cell proliferation. Cell–cell communication plays a crucial role in cell …