Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and
apoptosis by participating in multiple signaling pathways in the body. Studies have shown …

In the past two decades, significant progress has been made in the past two decades
towards the understanding of the basic mechanisms underlying cancer growth and …

Abstract Bladder Cancer (BLCa) inter-patient heterogeneity is the primary cause of treatment
failure, suggesting that patients could benefit from a more personalized treatment approach …

TSC2 is a tumor suppressor gene as well as a disease-causing gene for autosomal
dominant disorder tuberous sclerosis complex (TSC). Research has found that some tumor …

Although diagnosis of high-grade uterine mesenchymal tumors (UMTs) exhibiting classic
morphologic features is straightforward, diagnosis is more challenging in tumors in which …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the
presence of proliferative lesions throughout the body. Management of TSC is challenging …

Several elements highlight the importance of the mechanistic target of rapamycin (mTOR) in
the biology of renal cell carcinoma (RCC). mTOR signaling pathway is indeed frequently …

PI3Kα inhibitors have shown clinical activity in PIK3CA-mutated estrogen receptor-positive
(ER+) patients with breast cancer. Using whole genome CRISPR/Cas9 sgRNA knockout …

Chromophobe renal cell carcinoma (chRCC) is a histologically and molecularly distinct
class of rare renal tumor. TCGA studies revealed low mutational burden, with only TP53 and …

The aim of this study was to assess the histopathologic spectrum of renal tumors in patients
with PTEN hamartoma tumor syndrome (PHTS), with a specific focus on potential features …