Aminoglycosides have been an essential component of the armamentarium in the treatment
of life-threatening infections. Unfortunately, their efficacy has been reduced by the surge and …

Nephrotoxicity is one of the most important side effects and therapeutical limitations of
aminoglycoside antibiotics, especially gentamicin. Despite rigorous patient monitoring …

Due to high relative blood flow the kidney is prone to drug-induced damage.
Aminoglycoside type antibiotic gentamicin is one of the leading cause of drug-induced …

Pharmaceutical agents provide diagnostic and therapeutic utility that are central to patient
care. However, all agents also carry adverse drug effect profiles. While most of these are …

Aminoglycoside antibiotics are employed clinically because of their potent bactericidal
activities, less bacterial resistance, post-antibiotic effects and low cost. However, drugs …

The antidiabetic drug metformin can diminish apoptosis induced by oxidative stress in
endothelial cells and prevent vascular dysfunction even in nondiabetic patients. Here we …

The present investigation was designed to investigate the protective effect of (Beta vulgaris
L.) beat root ethanolic extract (BVEE) on gentamicin‐induced nephrotoxicity and to elucidate …

Gentamicin is an aminoglycoside antibiotic widely used against infections by Gram-negative
microorganisms. Nephrotoxicity is the main limitation to its therapeutic efficacy. Gentamicin …

BACKGROUND: End-stage kidney disease overwhelms health services in Central America.
We determined prevalences of decreased kidney function in distinct populations in the most …

Aminoglycosides (AGs) are long-known molecules successfully used against Gram-negative
pathogens. While their use declined with the discovery of new antibiotics, they are now …