Radiochemistry: a hot field with opportunities for cool chemistry

GD Bowden, PJH Scott, E Boros - ACS Central Science, 2023 - ACS Publications
Recent Food and Drug Administration (FDA) approval of diagnostic and therapeutic
radiopharmaceuticals and concurrent miniaturization of particle accelerators leading to …

Artificial intelligence in nuclear medicine: opportunities, challenges, and responsibilities toward a trustworthy ecosystem

B Saboury, T Bradshaw, R Boellaard… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Trustworthiness is a core tenet of medicine. The patient–physician relationship is evolving
from a dyad to a broader ecosystem of health care. With the emergence of artificial …

Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

D Lin, LM Lechermann, MP Huestis… - Angewandte Chemie …, 2024 - Wiley Online Library
This review discusses recent advances in light‐driven radiochemistry for three key isotopes:
fluorine‐18, carbon‐11, and zirconium‐89, and their applications in positron emission …

Copper-Mediated Radiocyanation of Unprotected Amino Acids and Peptides

LS Sharninghausen, S Preshlock, ST Joy… - Journal of the …, 2022 - ACS Publications
This report describes a copper-mediated radiocyanation of aryl halides that is applicable to
complex molecules. This transformation tolerates an exceptionally wide range of functional …

Accelerating radiochemistry development: Automated robotic platform for performing up to 64 droplet radiochemical reactions in a morning

J Jones, V Do, Y Lu, RM van Dam - Chemical Engineering Journal, 2023 - Elsevier
The growing discovery and development of novel radiopharmaceuticals and radiolabeling
methods requires an increasing capacity for radiochemistry experiments. However, such …

The development and validation of radiopharmaceuticals targeting bacterial infection

S Alberto, AA Ordonez, C Arjun… - Journal of Nuclear …, 2023 - Soc Nuclear Med
The International Atomic Energy Agency organized a technical meeting at its headquarters
in Vienna, Austria, in 2022 that included 17 experts representing 12 countries, whose …

In Silico Approaches for Addressing Challenges in CNS Radiopharmaceutical Design

IM Jackson, EW Webb, PJH Scott… - ACS chemical …, 2022 - ACS Publications
Positron emission tomography (PET) is a highly sensitive and versatile molecular imaging
modality that leverages radiolabeled molecules, known as radiotracers, to interrogate …

SNAr Radiofluorination with In Situ Generated [18F]Tetramethylammonium Fluoride

SJ Lee, MT Morales-Colón, AF Brooks… - The Journal of …, 2021 - ACS Publications
This report describes a method for the nucleophilic radiofluorination of (hetero) aryl
chlorides,(hetero) aryl triflates, and nitroarenes using a combination of [18F] KF· K2. 2.2 and …

Proceedings of international symposium of trends in radiopharmaceuticals 2023 (ISTR-2023)

A Jalilian, C Decristoforo, M Denecke… - EJNMMI …, 2023 - Springer
Abstract The International Atomic Energy Agency (IAEA) held the 3rd International
Symposium on Trends in Radiopharmaceuticals,(ISTR-2023) at IAEA Headquarters in …

[图书][B] Preparation of positron emission tomography (PET) tracers on advanced microvolume platforms

Y Lu - 2023 - search.proquest.com
Positron emission tomography (PET) is a widely-used nuclear medicine imaging technique
for assessing biodistribution of drugs, diagnosing diseases, and monitoring therapy …