Excessive activation of signal transducer and activator of transcription 3 (STAT3) signaling is
observed in a subset of many cancers, making activated STAT3 a highly promising potential …

Elevated levels of reactive oxygen species (ROS) are a hallmark of cancer. Although
increased ROS concentrations play important roles in cancer formation and progression …

Patients with cancer can go though many stages in their disease, including diagnosis,
recurrence, metastasis, and treatment failure. Cancer stem cells (CSCs) are a subgroup of …

Fibrolamellar carcinoma (FLC), a rare, lethal hepatic cancer, occurs primarily in adolescents
and young adults. Unlike hepatocellular carcinoma, FLC has no known association with …

Abstract Isocitrate dehydrogenase (IDH) 1 and 2, as essential enzymes in energy
metabolism, contribute to the survival and drug resistance of a variety of solid tumors …

Napabucasin, undergoing multiple clinical trials, was reported to inhibit the signal
transducer and transcription factor 3 (STAT3). To better elucidate its mechanism of action …

Redox modulators have been developed as an attractive approach to treat cancer. Herein,
we report the synthesis, identification, and biological evaluation of a quinazolinedione …

Background Compared with normal cells, tumour cells contain elevated levels of reactive
oxygen species (ROS). Increased levels of the antioxidant protein NAD (P) H: quinone …

To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated
patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and …

Abstract Background Cancer stem cells (CSCs) are crucial for the growth, metastasis, drug
resistance, recurrence, and spread of tumors. Napabucasin (NAP) could effectively inhibit …