Background The antiphospholipid syndrome (APS) is classified by the presence of
antiphospholipid antibodies (aPL) and thrombotic and/or adverse obstetric outcomes. The …

Background Patients with cirrhosis are at high risk of thrombotic events, including portal vein
thrombosis and venous thromboembolism. In such patients, hypercoagulability is not …

Abstract Background Thrombin generation assays (TGAs) performed with calibrated
automated thrombography (CAT) in the presence of thrombomodulin (TM) indicate plasma …

Introduction The bispecific antibody, emicizumab, is a prophylactic therapy used for the
treatment of haemophilia A (HA). Patients may require additional replacement factor VIII …

Background Monitoring of anticoagulant activity of direct oral anticoagulants (DOACs) can
be necessary in special situations. DOAC plasma levels have a high inter‐and …

Background The thrombin generation (TG) assay, which measures global coagulation, has
mainly been used as a research tool to investigate thrombotic and bleeding disorders …

Background Thrombin generation (TG) assessed by Calibrated Automated Thrombogram
(CAT-I) reflects the overall capacity of plasma to generate thrombin, thus evaluating the …

Background Mild to moderate bleeding disorders are a diagnostic challenge. Many patients
remain undiagnosed despite thorough and repeated laboratory testing. Thrombin …

Background The measurement of thrombin generation (TG) potential by the calibrated
automated thrombogram (CAT) assay provides a strong contribution in identifying patients at …

Abstract Introduction Thrombin generation assays (TGAs) assess the overall functionality of
the hemostatic system and thereby provide a reflection of the hemostatic capacity of patients …