The nerve growth factor-delivered signals in prostate cancer and its associated microenvironment: When the dialogue replaces the monologue

M Di Donato, P Giovannelli, A Migliaccio, G Castoria - Cell & Bioscience, 2023 - Springer
Prostate cancer (PC) represents the most diagnosed and the second most lethal cancer in
men worldwide. Its development and progression occur in concert with alterations in the …

Emerging role of IGF-1 in prostate cancer: a promising biomarker and therapeutic target

G Liu, M Zhu, M Zhang, F Pan - Cancers, 2023 - mdpi.com
Simple Summary Prostate cancer (PCa) affects millions of men globally, and approximately
20% of PCa patients are found after they develop into a lethal metastatic or castration …

A review on phytochemical composition and potential health-promoting properties of walnuts

THD Nguyen, DC Vu - Food Reviews International, 2023 - Taylor & Francis
Walnuts are among the commonly consumed oil nuts in the world. The nuts typically contain
40–70% oil, and are a rich source of fatty acids, phenolics, phytosterols, tocopherols and …

Periprostatic adipose tissue promotes prostate cancer resistance to docetaxel by paracrine IGF‐1 upregulation of TUBB2B beta‐tubulin isoform

A Liotti, E La Civita, M Cennamo, F Crocetto… - The …, 2021 - Wiley Online Library
Growing evidence supports the pivotal role played by periprostatic adipose tissue (PPAT) in
prostate cancer (PCa) microenvironment. We investigated whether PPAT can affect …

Connecting the dots between the gut–IGF-1–prostate Axis: a role of IGF-1 in prostate carcinogenesis

M Matsushita, K Fujita, K Hatano… - Frontiers in …, 2022 - frontiersin.org
Prostate cancer (PCa) is the most common malignancy in men worldwide, thus developing
effective prevention strategies remain a critical challenge. Insulin-like growth factor 1 (IGF-1) …

PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer

LA Caromile, K Dortche, MM Rahman, CL Grant… - Science …, 2017 - science.org
Increased abundance of the prostate-specific membrane antigen (PSMA) on prostate
epithelium is a hallmark of advanced metastatic prostate cancer (PCa) and correlates …

Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array

JL Welton, P Brennan, M Gurney… - Journal of …, 2016 - Taylor & Francis
Proteomics analysis of biofluid-derived vesicles holds enormous potential for discovering
non-invasive disease markers. Obtaining vesicles of sufficient quality and quantity for …

Obesity, inflammation, and advanced prostate cancer

A Olivas, RS Price - Nutrition and Cancer, 2021 - Taylor & Francis
Obesity is associated with high-grade and advanced prostate cancer. While this association
may be multi-factorial, studies suggest that obesity-induced inflammation may play a role in …

CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and mortality

C Sorrentino, L D'Antonio, SL Ciummo, C Fieni… - Journal of Hematology & …, 2022 - Springer
Background Metastatic prostate cancer (PC) is a leading cause of cancer death in men
worldwide. Targeting of the culprits of disease progression is an unmet need. Interleukin (IL) …

[HTML][HTML] The insulin-like growth factor system in multiple myeloma: diagnostic and therapeutic potential

L Bieghs, HE Johnsen, K Maes, E Menu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Multiple myeloma (MM) is a highly heterogeneous plasma cell malignancy. The MM cells
reside in the bone marrow (BM), where reciprocal interactions with the BM niche foster MM …