The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases
have emerged as critical regulators of immune responses. MARCH proteins target immune …

Successful transmission by viruses in the face of vigorous innate and acquired host
immunity requires the ability to evade, obstruct, or subvert critical elements that mediate host …

Efficient genetic modification of herpesviruses such as Kaposi's sarcoma-associated
herpesvirus (KSHV) has come to rely on bacterial artificial chromosome (BAC) technology …

Ubiquitination controls a broad range of cellular functions. The last step of the ubiquitination
pathway is regulated by enzyme type 3 (E3) ubiquitin ligases. E3 enzymes are responsible …

Poxviruses and gamma-2 herpesviruses share the K3 family of viral immune evasion
proteins that inhibit the surface expression of glycoproteins such as major histocompatibility …

ABSTRACT K3/MIR1 and K5/MIR2 of Kaposi's sarcoma-associated herpesvirus (KSHV) are
viral members of the membrane-associated RING-CH (MARCH) ubiquitin ligase family and …

Mitochondria serve as platforms for innate immunity. The mitochondrial antiviral signalling
(MAVS) protein forms aggregates that elicit robust type-I interferon induction on viral …

Porcine reproductive and respiratory syndrome virus (PRRSV) is the most important
infectious disease agent of pigs worldwide, causing reproductive failure in pregnant sows …

In early studies, herpes simplex virus 1 (HSV-1) proteins were identified on the basis of two
criteria. The first consisted of characterization of proteins contained in virions purified from …

Monkeypox virus (MPV) is a virulent human pathogen that has gained increased attention
because of its potential use as a bioterrorism agent and inadvertent introduction into North …