The world is currently undergoing a pandemic caused by an H1N1 influenza A virus, the so-
called'swine flu'. The H5N1 ('bird flu') influenza A viruses, now circulating in Asia, Africa and …

Highlights•Influenza A NS1 protein blocks interferon (IFN) production by one or two
mechanisms.•NS1 proteins of several virus strains do not inhibit activation of IFN …

RIG-I is a viral RNA sensor that induces the production of type I interferon (IFN) in response
to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin …

ISG15 is an IFN-α/β–induced, ubiquitin-like protein that is conjugated to a wide array of
cellular proteins through the sequential action of three conjugation enzymes that are also …

The non-structural protein 1 of influenza virus (NS1) is a relatively small polypeptide with an
outstanding number of ascribed functions. NS1 is the main viral antagonist of the innate …

Most viruses express one or several proteins that counter the antiviral defences of the host
cell. This is the task of non-structural protein NS1 in influenza viruses. Absent in the viral …

Since the influenza pandemic occurred in 1918, people have recognized the perniciousness
of this virus. It can cause mild to severe infections in animals and humans worldwide, with …

Influenza viruses are globally important human respiratory pathogens. These viruses cause
seasonal epidemics and occasional worldwide pandemics, both of which can vary …

Mosquito-borne flaviviruses, including yellow fever virus (YFV), Zika virus (ZIKV), and West
Nile virus (WNV), profoundly affect human health. The successful transmission of these …

Protein phosphorylation is a common post-translational modification in eukaryotic cells and
has a wide range of functional effects. Here, we used mass spectrometry to search for …