Hepatitis B surface antigen seroclearance: immune mechanisms, clinical impact, importance for drug development

I Tout, D Loureiro, A Mansouri, V Soumelis, N Boyer… - Journal of …, 2020 - Elsevier
HBsAg seroclearance occurs rarely in the natural history of chronic hepatitis B (CHB)
infection and is associated with improved clinical outcomes. Many factors are associated …

[HTML][HTML] Genetic variation of hepatitis B virus and its significance for pathogenesis

ZH Zhang, CC Wu, XW Chen, X Li, J Li… - World journal of …, 2016 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) has a worldwide distribution and is endemic in many populations.
Due to its unique life cycle which requires an error-prone reverse transcriptase for …

[PDF][PDF] Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression

R Salpini, L Colagrossi, MC Bellocchi, M Surdo… - …, 2015 - Wiley Online Library
Hepatitis B virus (HBV) reactivation during immunosuppression can lead to severe acute
hepatitis, fulminant liver failure, and death. Here, we investigated hepatitis B surface antigen …

[PDF][PDF] Hepatitis B and pregnancy: virologic and immunologic characteristics

SS Joshi, CS Coffin - Hepatology communications, 2020 - Wiley Online Library
The hepatitis B virus (HBV) is an important human pathogen. Unvaccinated infants infected
through mother‐to‐child transmission (MTCT) are at> 95% risk of developing serum …

[HTML][HTML] Genetic variation of occult hepatitis B virus infection

HL Zhu, X Li, J Li, ZH Zhang - World Journal of Gastroenterology, 2016 - ncbi.nlm.nih.gov
Occult hepatitis B virus infection (OBI), characterized as the persistence of hepatitis B virus
(HBV) surface antigen (HBsAg) seronegativity and low viral load in blood or liver, is a …

Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling

Y Lin, C Wu, X Wang, S Liu, K Zhao, T Kemper, H Yu… - Autophagy, 2020 - Taylor & Francis
Glucosamine (GlcN), a dietary supplement widely utilized to promote joint health and
effective in the treatment of osteoarthritis, is an effective macroautophagy/autophagy …

Molecular mechanisms during hepatitis B infection and the effects of the virus variability

M Campos-Valdez, HC Monroy-Ramírez… - Viruses, 2021 - mdpi.com
The immunopathogenesis and molecular mechanisms involved during a hepatitis B virus
(HBV) infection have made the approaches for research complex, especially concerning the …

Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA

K Xiang, E Michailidis, H Ding, Y Peng, M Su, Y Li… - Journal of …, 2017 - Elsevier
Background & Aims As important virological markers, serum hepatitis B surface antigen
(HBsAg) and hepatitis B virus (HBV) DNA levels show large fluctuations among chronic …

Cross-protection of hepatitis B vaccination among different genotypes

T Inoue, Y Tanaka - Vaccines, 2020 - mdpi.com
Hepatitis B (HB) vaccination is the most effective method for preventing HB virus (HBV)
infection. Universal HB vaccination containing recombinant HB surface antigens (HBsAg) is …

Human cytidine deaminases facilitate hepatitis B virus evolution and link inflammation and hepatocellular carcinoma

Y Deng, Y Du, Q Zhang, X Han, G Cao - Cancer letters, 2014 - Elsevier
During hepatitis B virus (HBV)-induced hepatocarcinogenesis, chronic inflammation
facilitates the evolution of hepatocellular carcinoma (HCC)-promoting HBV mutants. Cytidine …