Nucleic acid-based cancer biomarkers (NABCBs) have emerged as a notable and
continuously captivating research focal point within the domain of oncology. As a result …

Despite the recent advances in the prediction of protein structures by deep neutral networks,
the elucidation of protein-folding mechanisms remains challenging. A promising theory for …

A longstanding goal in the field of intrinsically disordered proteins (IDPs) is to characterize
their structural heterogeneity and pinpoint the role of this heterogeneity in IDP function …

Current predictors of DNA-binding residues (DBRs) from protein sequences belong to two
distinct groups, those trained on binding annotations extracted from structured protein-DNA …

Histone methylation is central to the regulation of eukaryotic transcription. In Saccharomyces
cerevisiae, it is controlled by a system of four methyltransferases (Set1p, Set2p, Set5p, and …

Statistical mechanical models that afford an intermediate resolution between macroscopic
chemical models and all-atom simulations have been successful in capturing folding …

Computational prediction of nucleic acid-binding residues in protein sequences is an active
field of research, with over 80 methods that were released in the past 2 decades. We identify …

Protein sequences and structures evolve by satisfying varied physical and biochemical
constraints. This multi-level selection is enabled not just by the patterning of amino acids on …

Abstract Brain Expressed X-linked (BEX) protein family consists of five members in humans
and is highly expressed during neuronal development. They are known to participate in cell …

N-terminal disulfide bond oxidoreductase (nDsbDOx/Red) proteins display divergent
substrate binding mechanisms depending on the conformational changes to the Phe70 cap …