Mucoadhesive polymeric platforms for controlled drug delivery

GP Andrews, TP Laverty, DS Jones - European journal of pharmaceutics …, 2009 - Elsevier
The process of mucoadhesion involving a polymeric drug delivery platform is a complex one
that includes wetting, adsorption and interpenetration of polymer chains amongst various …

The use of mucoadhesive polymers in ocular drug delivery

A Ludwig - Advanced drug delivery reviews, 2005 - Elsevier
In the present update on mucoadhesive ocular dosage forms, the tremendous advances in
the biochemistry of mucins, the development of new polymers, the use of drug complexes …

Permeability issues in nasal drug delivery

P Arora, S Sharma, S Garg - Drug discovery today, 2002 - Elsevier
The nasal route is one of the most permeable and highly vascularized site for drug
administration ensuring rapid absorption and onset of therapeutic action. It has been …

Mucoadhesive drug delivery systems

A Ahuja, RK Khar, J Ali - Drug Development and industrial …, 1997 - Taylor & Francis
Mucoadhesion in drug delivery systems has recently gained interest among pharmaceutical
scientists as a means of promoting dosage form residence time as well as improving …

Rheological properties and microstructures of Carbopol gel network system

JY Kim, JY Song, EJ Lee, SK Park - Colloid and Polymer Science, 2003 - Springer
Carbopol gel systems have been studied using steady, oscillatory rheology, and
cryoscanning electron microscopy (cryo-SEM) analysis in order to elucidate the nature of the …

Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine

A Bernkop-Schnürch, CE Kast, MF Richter - Journal of controlled release, 2001 - Elsevier
The purpose of the present study was to improve the mucoadhesive properties of alginate by
the covalent attachment of cysteine. Mediated by a carbodiimide, l-cysteine was covalently …

Nanoscale technology of mucoadhesive interactions

NA Peppas, Y Huang - Advanced drug delivery reviews, 2004 - Elsevier
Nanoscale analysis may be used to design new types of mucoadhesive polymers.
Understanding of the surface interactions between hydrophilic polymer surfaces and mucins …

A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration

F Madsen, K Eberth, JD Smart - Journal of controlled release, 1998 - Elsevier
The ability of mucoadhesive polymers to produce a large increase in the resistance to
deformation when incorporated into a mucus gel, relative to when the mucus gel and test …

Comparative rheological investigation of crude gastric mucin and natural gastric mucus

J Kočevar-Nared, J Kristl, J Šmid-Korbar - Biomaterials, 1997 - Elsevier
Mucus is a viscoelastic gel covering the entire alimentary tract. It represents a pre-epithelial
diffusion barrier influencing the drug absorption process. In this way the rheological …

Mucoadhesive delivery systems. I. Evaluation of mucoadhesive polymers for buccal tablet formulation

NA Nafee, FA Ismail, NA Boraie… - Drug development and …, 2004 - Taylor & Francis
Different types of mucoadhesive polymers, intended for buccal tablet formulation, were
investigated for their comparative mucoadhesive force, swelling behavior, residence time …