The specialized two-stage meiotic cell division program halves a cell's chromosome
complement in preparation for sexual reproduction. This reduction in ploidy requires that in …

BACKGROUND Meiosis is an essential stage in the life cycle of sexually reproducing
species, underlying formation of haploid gametes and serving as the basis of genetic …

Programmed DNA double-strand break (DSB) formation is a crucial feature of meiosis in
most organisms. DSBs initiate recombination-mediated linking of homologous …

One of the most fascinating aspects of meiosis is the extensive reorganization of the genome
at the prophase of the first meiotic division (prophase I). The first steps of this reorganization …

In the current meiotic recombination initiation model, the SPO11 catalytic subunits associate
with MTOPVIB to form a Topoisomerase VI-like complex that generates DNA double strand …

Proper number and placement of meiotic crossovers is vital to chromosome segregation,
with failures in normal crossover distribution often resulting in aneuploidy and infertility …

Meiosis requires the formation of programmed DNA double strand breaks (DSBs), essential
for fertility and for generating genetic diversity. DSBs are induced by the catalytic activity of …

Meiotic recombination is initiated by the formation of DNA double‐strand breaks (DSBs),
essential for fertility and genetic diversity. In the mouse, DSBs are formed by the catalytic …

The DSB machinery, which induces the programmed DNA double-strand breaks (DSBs) in
the leptotene and zygotene stages during meiosis, is suppressed before the onset of the …

Premature ovarian insufficiency (POI) is a clinically heterogeneous disease that may
seriously affect the physical and mental health of women of reproductive age. POI primarily …