Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Introduction: Chronic pain is a massive clinical problem. We discuss the potential of subtype
selective sodium channel blockers that may provide analgesia with limited side effects …

Voltage-gated sodium channel Nav1. 7 represents a promising target for pain relief. Here we
report the cryo–electron microscopy structures of the human Nav1. 7-β1-β2 complex bound …

Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …

In common with other chronic pain conditions, there is an unmet clinical need in the
treatment of inherited erythromelalgia (IEM). The SCN9A gene encoding the sodium …

Human studies have firmly implicated voltage-gated sodium channels in human pain
disorders, and targeted and massively parallel genomic sequencing is beginning to be used …

Abstract Na V 1.7, a subtype of the voltage-gated sodium channel family that is highly
expressed in peripheral sensory neurons, remains one of the most promising targets for the …

Acute pain is adaptive, but chronic pain is a global challenge. Many chronic pain syndromes
are peripheral in origin and reflect hyperactivity of peripheral pain-signaling neurons …

Primary erythromelalgia (PE ORPHA90026) is a rare autosomal dominant neuropathy
characterized by the combination of recurrent burning pain, warmth and redness of the …

Loss-of-function mutations in Nav1. 7, a voltage-gated sodium channel, cause congenital
insensitivity to pain (CIP) in humans, demonstrating that Nav1. 7 is essential for the …