The cullin-RING E3 ubiquitin ligase CRL4 Cdt2 has emerged as a master regulator of
genome stability, which targets key cell cycle proteins for proteolysis during S phase and …

Sliding clamps play a pivotal role in the process of replication by increasing the processivity
of the replicative polymerase. They also serve as an interacting platform for a plethora of …

The dysfunction of the ubiquitin–proteasome system (UPS) facilitates the malignant
progression of hepatocellular carcinoma (HCC). While targeting the UPS for HCC therapy …

The assembly of mammalian SWI/SNF chromatin remodeling complexes is developmentally
programed, and loss/mutations of SWI/SNF subunits alter the levels of other components …

Every time a cell copies its DNA the genetic material is exposed to the acquisition of
mutations and genomic alterations that corrupt the information passed on to daughter cells …

In eukaryotic cells, DNA replication licensing is precisely regulated to ensure that the
initiation of genomic DNA replication in S phase occurs once and only once for each mitotic …

Progression through the cell cycle is driven by bistable switches—specialized molecular
circuits that govern transitions from one cellular state to another. Although the mechanics of …

The maintenance of genome integrity is essential for cellular survival and propagation. It
relies upon the accurate and timely replication of the genetic material, as well as the rapid …

The CRL4Cdt2 ubiquitin ligase complex is an essential regulator of cell-cycle progression
and genome stability, ubiquitinating substrates such as p21, Set8, and Cdt1, via a display of …

Background Targeting ubiquitin-dependent proteolysis is one of the strategies in cancer
therapy. CRL CDT2 and CRL DDB2 are two key E3 ubiquitin ligases involved in DNA …