Before the first description of hay fever in 1870, there was very little awareness of allergic
disease, which is actually similar to the situation in prehygiene villages in Africa today. The …

Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of
action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors …

Pharmacokinetics Acetaminophen has a high oral bioavailability (88%); it is well absorbed
and reaches the peak blood concentration within 90min after ingestion [5]. APAP is not …

Background Paracetamol is used extensively during pregnancy, but studies regarding the
potential neurodevelopmental sequelae of foetal paracetamol exposure are lacking. Method …

Previous studies have suggested that asthma, like other common diseases, has at least part
of its origin early in life. Low birth weight has been shown to be associated with increased …

Introduction The purpose of this review was to discuss new issues related to safety, labeling,
dosing, and a better understanding of the analgesic effect of acetaminophen. Methods The …

Objectives This study examines awareness of the potential risks associated with over-the-
counter (OTC) use of paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) …

Background and objective While paracetamol exposure in pregnancy and early infancy has
been associated with asthma, it remains unclear whether this is confounded by respiratory …

Effective and safe drug administration in neonates should be based on integrated
knowledge on the evolving physiological characteristics of the infant who will receive the …

Background Several studies have reported an association between use of over-the-counter
antipyretics during pregnancy or infancy and increased asthma risk. An important potential …