Epilepsy is a common neurological disease in both humans and domestic dogs, making
dogs an ideal translational model of epilepsy. In both species, epilepsy is a complex brain …

Seizures have a profound impact on quality of life and mortality, in part because they can be
challenging both to detect and forecast. Seizure detection relies upon accurately …

Epilepsy is a challenging multifactorial disorder with a complex genetic background. Our
current understanding of the pathophysiology and treatment of epilepsy has substantially …

Objective This study was undertaken to evaluate how the challenges in the recruitment and
retention of participants in clinical trials for focal onset epilepsy have changed over time …

Abstract Objective Randomized controlled trials (RCTs) in epilepsy for drug treatments are
plagued by high costs. One potential remedy is to reduce placebo response via better …

Objective Intermittent rescue therapy may be used for seizure clusters, which are clinical
emergencies that may persist≥ 24 h and increase risk of status epilepticus, emergency …

Objective To evaluate the efficacy of open-label, highly purified cannabidiol (CBD,
Epidiolex®) in treating refractory epilepsy relative to the concomitant use of clobazam (CLB) …

Substantial efforts are underway toward optimizing the diagnosis, monitoring, and treatment
of seizures and epilepsy. We describe preclinical programs in place for screening …

Optogenetics, the use of light to control the activity of suitably sensitized cells, has led to
major advances in the field of basic neuroscience since it first emerged in 2005. Already, the …

Purpose: Animal and proof-of-principle human studies suggest that cathodal transcranial
direct current stimulation may suppress seizures in drug-resistant focal epilepsy. The …