The circulation of the lung is unique both in volume and function. For example, it is the only
organ with two circulations: the pulmonary circulation, the main function of which is gas …

The pulmonary circulation is a low‐pressure, low‐resistance vascular bed with little to no
resting tone under normal conditions. An increase in the [Ca2+] i in PASMC s is an important …

Hypoxia and intracellular Ca 2+ transients are fundamental traits of cancer, whereas the
route and regulation of Ca 2+ mobilization in hypoxic tumorigenesis are unknown. Here, we …

The incidence of woody breast (WB) is increasing on a global scale representing a
significant welfare problem and economic burden to the poultry industry and for which there …

Ca2+ signaling in pulmonary arterial smooth muscle cells (PASMCs) plays an important role
in pulmonary hypertension (PH). However, the underlying specific ion channel mechanisms …

The renascence in mitochondrial research has fueled breakthroughs in our understanding of
mitochondrial biology identifying major roles in biological processes ranging from cellular …

Hypoxia-induced pulmonary vasoconstriction (HPV) is attributed to an increase in
intracellular Ca2+ concentration ([Ca2+] i) in pulmonary artery smooth muscle cells …

Aims: It is known that mitochondrial reactive oxygen species generation ([ROS] m) causes
the release of Ca2+ via ryanodine receptor-2 (RyR2) on the sarcoplasmic reticulum (SR) in …

Reactive oxygen species (ROS) are frequently seen as pathological agents of oxidative
stress. However, ROS are not always deleterious and can also act as cell signaling …

Hypoxic pulmonary vasoconstriction (HPV) occurs during both fetal and postnatal
development and plays a critical role in matching regional alveolar perfusion with ventilation …