Ocular drug delivery barriers—role of nanocarriers in the treatment of anterior segment ocular diseases

RD Bachu, P Chowdhury, ZHF Al-Saedi, PK Karla… - Pharmaceutics, 2018 - mdpi.com
Ocular drug delivery is challenging due to the presence of anatomical and physiological
barriers. These barriers can affect drug entry into the eye following multiple routes of …

Polymer-based carriers for ophthalmic drug delivery

JC Imperiale, GB Acosta, A Sosnik - Journal of controlled release, 2018 - Elsevier
Despite the wide range of diseases affecting the eye, ocular bioavailability remains a
challenge in ophthalmic drug delivery. Nowadays an extensive variety of polymers are being …

Novel strategies for anterior segment ocular drug delivery

K Cholkar, SP Patel, AD Vadlapudi… - Journal of ocular …, 2013 - liebertpub.com
Research advancements in pharmaceutical sciences have led to the development of new
strategies in drug delivery to anterior segment. Designing a new delivery system that can …

Controlled ocular drug delivery with nanomicelles

RD Vaishya, V Khurana, S Patel… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
Many vision threatening ocular diseases such as age‐related macular degeneration (AMD),
diabetic retinopathy, glaucoma, and proliferative vitreoretinopathy may result in blindness …

Novel nanomicellar formulation approaches for anterior and posterior segment ocular drug delivery

K Cholkar, A Patel, A Dutt Vadlapudi… - Recent patents on …, 2012 - ingentaconnect.com
One of the most challenging areas of pharmaceutical research is ocular drug delivery. The
unique anatomy and physiology of the eye impedes drug permeation to deeper ocular …

Polymeric micelles in mucosal drug delivery: Challenges towards clinical translation

A Sosnik, MM Raskin - Biotechnology advances, 2015 - Elsevier
Polymeric micelles are nanostructures formed by the self-aggregation of copolymeric
amphiphiles above the critical micellar concentration. Due to the flexibility to tailor different …

Advanced nanodelivery platforms for topical ophthalmic drug delivery

S Gholizadeh, Z Wang, X Chen, R Dana, N Annabi - Drug discovery today, 2021 - Elsevier
Highlights•Eye drops are applied at high frequency due to unique physio-anatomy of
corneal tissue.•Different types of nanodelivery platforms (medical devices) have been …

[HTML][HTML] Topical, aqueous, clear cyclosporine formulation design for anterior and posterior ocular delivery

K Cholkar, BC Gilger, AK Mitra - Translational vision science & …, 2015 - iovs.arvojournals.org
Purpose:: The main objective of this study was to optimize cyclosporine (CsA) nanomicellar
solution and study in vivo ocular CsA tissue distribution with a topical drop. Methods:: An …

Barrier layer with underlying medical device and one or more reinforcing support structures

SA Herweck, J Ferraro, P Martakos, T Karwoski… - US Patent …, 2016 - Google Patents
1948, 959 A 2f1934 Croce 2,368,306 A 1/1945 Kiefer et al. 2,403.458 A 7, 1946 Ransom
2,735,814 A 2f1956 Hodson et al. 2.986, 540 A 5/1961 Posnansky 3,464,413 A 9, 1969 …

Nanoemulsion as oral drug delivery-a review

KB Sabjan, SM Munawar, D Rajendiran… - … : Current Drug Abuse …, 2020 - ingentaconnect.com
Background: Objective: The stability and delivery of drugs remain one of the key hurdles in
the present situation. The present study depends on the design of a novel nanoemulsion …