The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit
information bidirectionally across the plasma membrane, and plays a critical role in …

Drug candidate and toxicity screening processes currently rely on results from early-stage in
vitro cell-based assays expected to faithfully represent essential aspects of in vivo …

During embryogenesis and tissue maintenance and repair in an adult organism, a myriad of
stem cells are regulated by their surrounding extracellular matrix (ECM) enriched with …

Starting 90 years ago with a clinical description by Glanzmann of a bleeding disorder
associated with a defect in platelet function, technologic advances helped investigators …

Platelet aggregation is a critical event in thrombus formation and thus has extensive
involvement in physiological and pathological processes. The aggregation response …

Osteoclasts, the sole bone‐resorbing cells, arise by fusion and differentiation of monocyte/
macrophage precursors. Matrix degradation requires adhesion of the osteoclast to bone, an …

Integrin activation is essential for dynamically linking the extracellular environment and
cytoskeletal/signaling networks. Activation is controlled by integrins' short cytoplasmic tails …

Cells sense mechanical stress and changes in their matrix environment through the
integrins, a family of heterodimeric surface receptors that bind to extracellular matrix ligands …

The αvβ3 integrin is known to be highly upregulated during cancer progression and
promotes a migratory and metastatic phenotype in many types of tumors. We hypothesized …