Abstract α, α-Disubstituted α-amino acids (α-AAs) have improved properties compared to
other types of amino acids. They serve as modifiers of peptide conformation and as …

Unnatural chiral α-tertiary amino acids containing two different carbon-based substituents at
the α-carbon centre are widespread in biologically active molecules. This sterically rigid …

Stereoselective synthesis of acyclic α,α-disubstituted α-amino acids derivatives from amino acids
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Biosynthesis utilizes kinetic strategies to regulate the chemoselectivity for the
transformations of molecules containing multiple active reaction sites. But it is a grand …

Quaternary amino acids, in which the α-carbon that bears the amino and carboxyl groups
also carries two carbon substituents, have an important role as modifiers of peptide …

Available α‐amino acids undergo arylation at their α position in an enantioselective manner
on treatment with base of N′‐aryl urea derivatives ligated to pseudoephedrine as a chiral …

A Pd-catalyzed asymmetric allylic alkylation of azlactones with 4-arylvinyl-1, 3-dioxolan-2-
ones was developed, providing “branched” chiral α-amino acids with vicinal tertiary and …

This review describes the recent advances in asymmetric reactions based on memory of
chirality. The memory of chirality is a unique concept concerning an advanced type of chiral …

Stable helical molecular structures are ubiquitous in both biological and synthetic
polymers,[1] and in general the handedness (screw-sense) of a helical polymer is dictated …

Asymmetric α-Arylation of Amino Acid Derivatives by Clayden Rearrangement of Ester Enolates
via Memory of Chirality | Journal of the American Chemical Society ACS ACS Publications …