Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to
modulate their morphology, distribution, and function, which are referred as 'mitochondrial …

Pulmonary arterial hypertension (PAH) remains a mysterious killer that, like cancer, is
characterized by tremendous complexity. PAH development occurs under sustained and …

Pulmonary arterial hypertension (PAH) is a progressive vascular disease with a high
mortality rate. It is characterized by an occlusive vascular remodeling due to a pro …

Background: Pulmonary arterial hypertension (PAH) is characterized by abnormal growth
and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms …

Background: An emerging metabolic theory of pulmonary hypertension (PH) suggests that
cellular and mitochondrial metabolic dysfunction underlies the pathology of this disease. We …

Rationale: Right ventricular (RV) fibrosis in pulmonary arterial hypertension contributes to
RV failure. While RV fibrosis reflects changes in the function of resident RV fibroblasts …

Fibroblasts are the major cell population in the connective tissue of most organs, where they
are essential for their structural integrity. They are best known for their role in remodelling …

Significance: Mitochondria are the energetic, metabolic, redox, and information signaling
centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae …

The lung is often overlooked as a metabolically active organ, yet biochemical studies have
long demonstrated that glucose utilization surpasses that of many other organs, including …

This review seeks to provide an update of preclinical findings and available clinical data on
the chronic persistent inflammation and its direct role on the pulmonary arterial hypertension …